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目的:观察贝前列素钠联合甲钴胺治疗糖尿病并心脏自主神经病变的疗效和安全性。方法:选择糖尿病并心脏自主神经病变住院患者120例随机分为观察组和对照组。两组患者均接受降糖治疗。在此基础上,观察组患者予贝前列素钠联合甲钴胺治疗,对照组给予安慰剂治疗。共治疗12周。治疗前后检查两组患者24h动态心电图,采用动态心电图和心率变异性分析软件分析,包括时域分析和频域分析;检测受试者正中神经传导速度。比较两组疗效及药品不良反应。结果:治疗后,两组患者心脏自主神经功能均较治疗前明显改善(P<0.05);且观察组各项指标均明显优于较对照组(P<0.05)。观察组患者治疗后心脏自主神经功能自觉症状评分明显降低(P<0.05);且明显优于对照组(P<0.05)。观察组总有效率为85.0%,明显高于对照组的45.0%(P<0.05)。结论:甲钻胺联合贝前列素钠治疗心脏自主神经病变疗效肯定,安全性好,值得临床推广应用。
Objective: To observe the efficacy and safety of beraprost sodium combined with mecobalamin in the treatment of diabetic and cardiac autonomic neuropathy. Methods: A total of 120 hospitalized patients with diabetes and cardiac autonomic neuropathy were randomly divided into observation group and control group. Both groups received hypoglycemic treatment. On this basis, the observation group was treated with beraprost sodium and mecobalamin, while the control group was given placebo. A total of 12 weeks of treatment. 24h before and after treatment, check the two groups of patients with dynamic ECG, using dynamic electrocardiogram and heart rate variability analysis software analysis, including time domain analysis and frequency domain analysis; test subjects median nerve conduction velocity. The curative effect and drug adverse reactions of the two groups were compared. Results: After treatment, the function of cardiac autonomic nerves in both groups was significantly improved (P <0.05), and the indexes in the observation group were significantly better than those in the control group (P <0.05). The score of subjective autonomic nervous function symptom in observation group was significantly lower (P <0.05), and was significantly better than that in control group (P <0.05). The total effective rate in the observation group was 85.0%, which was significantly higher than that in the control group (45.0%, P <0.05). Conclusion: Methimazole combined with beraprost sodium has certain therapeutic effect on cardiac autonomic neuropathy. It is safe and worthy of clinical application.