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目的 研究腹腔注射卵清白蛋白致大鼠内脏高敏感与肥大细胞功能的关联。方法 腹腔注射鸡卵清白蛋白使大鼠内脏致敏 ,分别在给药 3天及 2周后用特殊染色法观察结肠肥大细胞的形态学改变。用腹部撤离反射 (Ab dominalwithdrawalreflex ,AWR)评估致敏大鼠对直肠扩张刺激的内脏感
Objective To study the correlation between the visceral hypersensitivity and mast cell function induced by intraperitoneal injection of ovalbumin in rats. Methods Intraperitoneal injection of chicken egg white albumin sensitized the visceral organs of rats. Morphological changes of colon mast cells were observed by special staining after 3 days and 2 weeks respectively. The visceral sensitivities of sensitized rats to rectal distension stimuli were evaluated using Abdominal withdrawal reflex (AWR)