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应用LSAB免疫组化法和酶联亲和组化法对41例胃癌P53蛋白和雌激素受体（ER）、孕激素受体（PR）的表达进行研究。结果显示：胃癌中P53蛋白、ER、PR的阳性率分别为41．46％、21．95％、14．63％。P53蛋白表达与肿瘤组织学分级、浸润汉度、临床分期及淋巴结转移呈正相关，与ER、PR表达呈负相关。在ER、PR阴性者中P53蛋白阳性中高于ER、PR阳性者。P53蛋白表达与组织学类型无关。提示检测P53蛋白、ER、PR的表达，可作为判断胃癌细胞增殖程度、转移潜能及预后和内分泌治疗有效率的重要参考指标。
LSAB immunohistochemistry and enzyme-linked immunohistochemistry were used to study the expression of P53 protein, estrogen receptor (ER) and progesterone receptor (PR) in gastric cancer. The results showed that the positive rates of P53 protein, ER, and PR in gastric cancer were 41.46%, 21.95%, and 14.63%, respectively. The expression of P53 protein was positively correlated with tumor histological grade, infiltration Han, clinical stage and lymph node metastasis, and negatively correlated with the expression of ER and PR. In patients with ER or PR negative, P53 protein positive was higher than ER, PR positive. P53 protein expression has nothing to do with the histological type. The detection of the expression of P53 protein, ER, and PR can be used as an important reference for judging the proliferation of gastric cancer cells, their metastatic potential, and the efficiency of prognosis and endocrine therapy.