[目的 ]　比较国产和进口水痘疫苗免疫效果 ,了解宝山区儿童水痘—带状疱疹病毒 (VZV)自然感染情况。　[方法 ]　随机选择 2 6 5名无水痘病史的 0～ 7岁儿童调查血清抗VZV -IgG阳性率 ;选择 84名 1～ 2岁VZV易感儿童随机分成两组 ,分别接种国产和进口水痘疫苗 ,免疫后 6周采血 ,用酶联免疫吸附试验检测抗VZV -IgG。　 [结果 ]　 1～ 7岁儿童抗VZV -IgG阳性率分别为 2 .0 0 %、11.11%、2 0 .0 0 %、17.6 5 %、30 .77%、40 .0 0 %、32 .14 % ;免前抗VZV -IgG阴性儿童 ,分别接种国产和进口水痘疫苗后 ,抗体阳转率分别为 90 .70 % ( 39/43)和 95 .12 % ( 39/41) ,两者差别无显著性 ;两种疫苗的抗VZV-IgG几何平均滴度倒数 (GMRT)分别为 2 0 4.848( 95 %CI190 .73～ 2 6 0 4.79)和 482 .6 9( 95 %CI93.30～ 2 497.5 ) ,进口疫苗GMRT略高于国产疫苗。　 [结论 ]　宝山区婴幼儿 6个月内部分存在VZV -IgG母体免疫 ,7个月后母体免疫消失 ;国产水痘疫苗免疫效果良好 ,本区 1～ 7岁儿童是易感人群 ,尤其是 1～ 4岁易感儿童适宜接种 [Objective] To compare the immune effects of domestic and imported chickenpox vaccines and understand the natural infection of children’s chickenpox-herpes zoster virus (VZV) in Baoshan District. [Methods] A total of 266 children aged 0-7 years without chickenpox were randomly selected to investigate the positive rate of anti-VZV-IgG in serum. Eighty-four VZV susceptible children aged 1-2 years were randomly divided into two groups and inoculated with domestic and imported chickenpox vaccine Blood was collected 6 weeks after immunization and anti-VZV-IgG was detected by enzyme-linked immunosorbent assay. [Results] The positive rates of anti-VZV-IgG in children aged 1 ~ 7 years were 2.0%, 11.11%, 20.0%, 17.65%, 30.77%, 40.0%, 32.14 % Respectively. The positive rates of antibody positive immunization were 90.70% (39/43) and 95.12% (39/41) respectively after immunization of domestic and imported chickenpox vaccines against pre-anti-VZV-IgG negative children (GMRT) of the two vaccines were 20 4.848 (95% CI 190.07 ~ 26.0479) and 482.69 (95% CI 93.30 ~ 2 497.5 ), Imported vaccine GMRT slightly higher than the domestic vaccine. [Conclusion] The prevalence of VZV-IgG immunization in infants in Baoshan district within 6 months and maternal immunity disappeared after 7 months. The immunization effect of domestic varicella vaccine was good. The children aged from 1 to 7 were predominant in this area, 4-year-old susceptible children suitable for vaccination