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目的探讨血清糖链抗原125(CA125)、糖链抗原199(CA199)及人附睾分泌蛋白4(HE4)检测对卵巢癌的诊断价值。方法选取行手术治疗的卵巢肿瘤患者220例,根据术后病理结果,将患者分为卵巢癌组52例和卵巢良性肿瘤组168例,另选取健康体检者100例作为健康组。比较3组血清CA125、CA199、HE4水平以及单独检测与联合检测卵巢癌的阳性率。结果卵巢恶性肿瘤患者血清CA125、CA199及HE4水平均高于良性肿瘤组和健康组,差异均有统计学意义(P<0.05)。良性肿瘤组患者CA125及CA199水平均高于健康组,差异均有统计学意义(P<0.05)。血清CA125、CA199及HE4联合检测卵巢癌的阳性率均高于血清CA199、HE4单独检测,差异均有统计学意义(P<0.05)。结论卵巢癌患者血清CA125、CA199、HE4均显著高于卵巢癌良性患者及健康者,三项指标的血清学检测对卵巢癌的早期诊断及鉴别具有重要的临床意义。
Objective To investigate the diagnostic value of serum carbohydrate antigen 125 (CA125), carbohydrate chain antigen 199 (CA199) and human epididymal secretory protein 4 (HE4) in ovarian cancer. Methods Totally 220 patients with ovarian tumors undergoing surgical treatment were divided into two groups: ovarian cancer group (52 cases) and ovarian benign tumor group (168 cases), and the other 100 healthy subjects were selected as healthy group according to the postoperative pathological results. The serum levels of CA125, CA199 and HE4 in the three groups were compared, and the positive rates of single detection and combined detection of ovarian cancer were also compared. Results The levels of serum CA125, CA199 and HE4 in patients with ovarian cancer were significantly higher than those in benign tumors and healthy controls (P <0.05). The levels of CA125 and CA199 in patients with benign tumor were significantly higher than those in healthy group (P <0.05). The positive rates of serum CA125, CA199 and HE4 combined detection of ovarian cancer were higher than that of serum CA199 and HE4 alone, with statistical significance (P <0.05). Conclusions Serum CA125, CA199 and HE4 in patients with ovarian cancer are significantly higher than those in benign and healthy patients with ovarian cancer. The serological detection of three indicators has an important clinical significance in the early diagnosis and differential diagnosis of ovarian cancer.