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目的观察不同浓度的大黄提取液对小鼠离体子宫平滑肌收缩性能的影响。方法采用离体器官实验法,将经过己烯雌酚预处理的小鼠急性处死,取出子宫置于恒温通气麦氏浴槽中,分别加入催产素和不同浓度的大黄提取液,记录子宫平滑肌收缩张力、收缩频率、收缩波的持续时间。结果随着大黄提取液浓度的增加,小鼠子宫平滑肌收缩性能随之降低。结论大黄提取液对小鼠离体子宫平滑肌条运动具有抑制作用。
Objective To observe the effects of different concentrations of rhubarb extract on contractility of isolated uterine smooth muscle in mice. Methods Ex vivo organ test was used to inoculate the mice pretreated with diethylstilbestrol. The uterus was removed and placed in a thermostat-ventilated Maxwell’s bath. Oxytocin and different concentrations of rhubarb extracts were added respectively. The contractile tension and contractile frequency of uterine smooth muscle were recorded , The duration of contraction wave. Results With the increase of rhubarb extract concentration, the contractility of mouse uterine smooth muscle decreased. Conclusion rhubarb extract on the uterine smooth muscle strips in vitro inhibition.