论文部分内容阅读
目的观察晚期非小细胞肺癌患者合并抑郁的发生率及其与预后的相关性。方法应用Zung′s抑郁自评量表,对83例晚期肺癌患者(A组)在化疗前及4次化疗后进行抑郁情绪的评估;对抑郁者进行抗抑郁治疗;观察患者一年生存率。同时对100例正常人(B组)进行抑郁情绪评估。结果 A组较B组更容易产生抑郁(P<0.05);初诊时抑郁的晚期肺癌患者的一年生存率比无抑郁者的一年生存率低(P<0.05)。结论晚期肺癌患者的抑郁是普遍存在的。初诊晚期肺癌患者如伴有抑郁可能提示生存时间较短,预后较差;抑郁与晚期肺癌预后之间可能存在一定的相关性。
Objective To investigate the incidence of postoperative depression in patients with advanced non-small cell lung cancer and its correlation with prognosis. Methods Eighty-three patients with advanced lung cancer (group A) were evaluated with Zung’s depression self-rating scale before and after four cycles of chemotherapy. Antidepressants were administered to depression patients. The one-year survival rate was observed. At the same time, 100 normal subjects (group B) were evaluated for depression. Results Group A was more prone to depression than group B (P <0.05). One-year survival rate of patients with advanced lung cancer with depression at first visit was lower than that without depression (P <0.05). Conclusions Depression in patients with advanced lung cancer is prevalent. Patients with newly diagnosed advanced lung cancer, if accompanied by depression, may indicate shorter survival time and poorer prognosis. There may be some correlation between depression and prognosis of advanced lung cancer.