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[目的]了解海南树仔菜对大鼠胚胎毒性及致畸性。[方法]将孕鼠随机分成4组(阴性对照组、树仔菜干粉低、中、高剂量组),每组12只。于受孕的d7～16,各组分别灌胃给予树仔菜干粉0,250,500,1000mg/kg,于受孕的d0、7、12、16、20称体重。d20断头处死孕鼠,检查胎鼠的死亡情况、外观、体重、体长、尾长。1/2胎鼠制作内脏标本,其余制作骨骼标本。[结果]各剂量组孕鼠体重、胚胎形成与发育、各项畸形指标与阴性对照组比较,差异无统计学意义(P﹥0.05)。[结论]海南树仔菜无母体毒性、胚胎毒性及致畸性。
[Objective] To understand the toxicity and teratogenicity of Hainan sambar on rat embryo. [Methods] Pregnant mice were randomly divided into 4 groups (negative control group, Shizuoka dry powder low, medium and high dose group), 12 in each group. At d7 ~ 16 of conception, the rats in each group were given ginseng root ointment 0,250,500,1000mg / kg by gavage, and weighed at d0,7,12,16,20 of conception. d20 decapitated pregnant rats, check the fetal rat death, appearance, weight, body length, tail length. 1/2 fetal rat visceral specimens, the rest of the production of bone specimens. [Result] There was no significant difference in weight, embryogenesis and development between the pregnant rats in each dose group and the negative control group (P> 0.05). [Conclusion] Hainan tree Tsai vegetables without maternal toxicity, embryotoxicity and teratogenicity.