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对国产痘苗病毒乙肝基因工程疫苗（北京生物制品研究所研制）和地鼠卵巢细胞乙肝基因工程疫苗（长春生物制品研究所研制）进行阻断乙肝母婴传播的效果观察，剂量为２０μｇ／支×３，接种ＨＢｓＡｇ和ＨＢｅＡｇ均阳性母亲的新生儿各４０例，观察时间≥９个月者分别为３３例和２９例。结果：全部新生儿均无局部或全身不良反应，Ｔ１时抗－ＨＢｓ阳转率分别为３．０％和１３．８％；Ｔ９时达高峰，分别为７８．８％和７９．３％；疫苗保护率分别为７９．２％和８０．２％；抗－ＨＢｓ滴度（Ｓ／Ｎ均值）Ｔ９时为高峰，分别为１１３．０４和９９．１１。各组中均有１例抗－ＨＢｓ和ＨＢｓＡｇ同时持续阳性；并分别有１例和２例抗－ＨＢｓ均持续阴性。结果表明国产乙肝基因工程疫苗均有良好的安全性和免疫原性，其阻断乙肝母婴传播的效果较同剂量血源疫苗好，与３０μｇ血源疫苗的阻断效果相近。
The effect of blocking the mother-to-child transmission of hepatitis B was observed in domestic vaccinia virus hepatitis B genetically engineered vaccine (Beijing Institute of Biological Products) and hamster ovary cell hepatitis B gene engineering vaccine (Changchun Institute of Biological Products) at a dose of 20 μg / 40 newborns vaccinated with HBsAg and HBeAg positive mothers each had 40 cases and the observation time was 9 months and 33 cases and 29 cases respectively. Results: All newborns had no local or systemic side effects. The positive rate of anti-HBs was 3.0% and 13.8% at T1, and reached 78.8% and 79.3% respectively at T9. The vaccine protection rates were 79.2% and 80.2%, respectively. The titer of anti-HBs (S / N mean) peaked at T9, which were 113.04 and 99.11, respectively. In both groups, 1 case of anti-HBs and HBsAg sustained positive at the same time, and 1 case and 2 cases of anti-HBs were negative. The results showed that domestic hepatitis B genetically engineered vaccine has good safety and immunogenicity, the effect of blocking the mother-to-child transmission of hepatitis B than the same dose of blood-borne vaccine is good, and 30-g blood vaccine similar blocking effect.