长期以来,还沒有一种抗瘧药能在体內维持作用半个月以上。最近国外发现了一种长效抗瘧药CI-501(环氯胍的次甲基双羟萘酸盐)。 Coatney等在“志願者”身上进行了试验,共试验51人,其中28人(分三组)一次肌注5毫克/公斤体重,23人为对照。第一组10人注药后定期反复用感染间日瘧原虫的四斑按蚊叮咬,结果8例接种1～5次者均未感 For a long time, no anti-malaria drug has been able to maintain its effect in the body for more than half a month. Recently abroad found a long-acting anti-malaria drug CI-501 (Cycloguanidine methine pamoate). Coatney and other volunteers in the body were tested, a total of 51 people were tested, of which 28 (divided into three groups) intramuscular injection of 5 mg / kg body weight, 23 were controlled. The first group of 10 people injected regularly after repeated infection with Plasmodium vivax Anopheles bites, the results of 8 cases of inoculation 1 to 5 times were not felt