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目的 探讨Ｔ 细胞在格林－巴利综合征（ＧＢＳ）发病机制中的作用。方法 应用ＥＬＩＳＡ 双抗体夹心法，检测３１ 例ＧＢＳ患者血浆白介素（ＩＬ－２）和可溶性白介素－２ 受体（ｓＩＬ－２Ｒ）浓度。结果 ３１ 例ＧＢＳ患者ＩＬ－２ 和ｓＩＬ－２Ｒ 浓度明显高于对照组（Ｐ＜ ０．００１） ， 且增高的程度与临床分级显著相关 （Ｐ ＜０．０５）。１６ 例接受糖皮质激素治疗病情好转的恢复期患者ＩＬ－２ 和ｓＩＬ－２Ｒ 浓度相应下降至正常或接近正常。结论 结果提示Ｔ 细胞可能在周围神经脱髓鞘的病理损害的发病机制中起着十分重要的作用。
Objective To investigate the role of T cells in the pathogenesis of Guillain-Barre Syndrome (GBS). Methods The concentrations of interleukin 2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) in 31 patients with GBS were detected by ELISA double antibody sandwich method. Results The concentrations of IL-2 and sIL-2R in 31 patients with GBS were significantly higher than those in the control group (P <0.001), and the level of IL-2 and sIL-2R was significantly correlated with clinical grade (P <0.05). The concentration of IL-2 and sIL-2R in convalescent patients of 16 patients receiving glucocorticoid treatment improved to normal or nearly normal. Conclusion The results suggest that T cells may play a very important role in the pathogenesis of pathological lesions of peripheral nerve demyelination.