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作为放疗和化疗的一种辅助措施,加温目前正被实验性地用于癌症的治疗。同许多抗癌疗法一样,其弊端之一是对正常细胞的毒性,造血过程是一个依赖于干细胞群分化的自我更新系统,因此对各种治癌疗法引起的紊乱十分敏感。本文报导了不同系造血祖细胞对热疗敏感性的差异。实验用B6D2F_1雄性小鼠,2～3月龄,用α培养液加20mM吗啉代丙磺酸(MOPS)及10%胎牛血清制成骨髓细胞悬液,以1×10~7/毫升的细胞浓度经42℃,
As an adjunct to radiotherapy and chemotherapy, warming is currently being used experimentally for the treatment of cancer. Like many anti-cancer therapies, one of its drawbacks is its toxicity to normal cells. The hematopoietic process is a self-renewal system that relies on the differentiation of stem cell populations and is therefore sensitive to disorders caused by various cancer treatments. This article reports the differences in the sensitivity of different hematopoietic progenitor cells to hyperthermia. Experimental B6D2F1 male mice, 2 to 3 months old, were cultured with α broth plus 20 mM morpholinopropanesulfonic acid (MOPS) and 10% fetal bovine serum to make a bone marrow cell suspension at 1×10~7/ml The cell concentration is 42°C.