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对41例甲亢患者、11例甲低患者和26例对照者的血清ApoA_1、ApoB_(100)和TC、TG、HDL_(-c)、LDL_(-c)水平进行了对比观察。结果发现,甲亢组ApoA_1、ApoB_(100)、TC、TG、HDL_(-c)、LDL_(-c)明显低于正常对照组。甲亢早期最早改变的是ApoB_(100)及A-1/B_(100),方差分析提示随着病程的延长ApoB_(100)逐渐降低,相关性分析提示血清T_3、T_4和ApoA_1、ApoB_(100)、TC、TG、LDL_(-c)均呈明显的负相关。治疗后ApoA_1、ApoB_(100)、TC、TG、LDL_(-c)均可在短期内机恢复正常。ApoA_1和A-1/B_(100)比值改变是判断病情、病程及疗效的灵敏指标。
The levels of serum ApoA_1, ApoB_ (100) and TC, TG, HDL_ (- c) and LDL_ (- c) in 41 patients with hyperthyroidism, 11 patients with hypothyroidism and 26 controls were compared. The results showed that ApoA_1, ApoB_ (100), TC, TG, HDL_ (- c) and LDL_ (- c) in hyperthyroidism group were significantly lower than those in normal control group. ApoB_ (100) and A-1 / B_ (100) were the first to be changed in the early stage of hyperthyroidism. Analysis of variance showed that ApoB_ (100) decreased gradually with the prolongation of the duration of disease. Correlation analysis indicated that serum levels of T_3, T_4, ApoA_1, ApoB_ (100) , TC, TG, LDL _ (- c) showed a significant negative correlation. After treatment, ApoA_1, ApoB_ (100), TC, TG and LDL_ (- c) all returned to normal within a short time. ApoA_1 and A-1 / B_ (100) changes in the ratio to determine the disease, duration and efficacy of sensitive indicators.