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通过角叉菜胶诱发大鼠足水肿这一经典炎症模型,观察了基因工程重组人铜锌超氧化物歧化酶(Recombined Human Superoxide Dismutase;rh SOD)对非感染性炎症的抗炎作用,证实了静脉注射 rh SOD(7000 U/kg～10 000 U/kg)对大鼠足肿胀有明显抑制作用,实验组与对照组间有显著性差异(P<0.001),增加剂量和给药次数可提高抗炎效果.该结果为进一步探讨rh SOD抗放射线损伤的机制奠定了基础.
The anti-inflammatory effect of recombinant human Superoxide dismutase (rh SOD) on noninfectious inflammation was observed through a classic inflammatory model of carrageenan-induced foot edema in rats. It was confirmed that Intravenous rh SOD (7000 U / kg ~ 10 000 U / kg) significantly inhibited foot swelling in rats, there was a significant difference between the experimental group and the control group (P <0.001), increasing the dosage and frequency of administration can be increased Anti-inflammatory effect.This result lays the foundation for further exploring the mechanism of rh SOD anti-radiation damage.