论文部分内容阅读
目的探讨高血压脑出血患者脑脊液中β-内啡肽含量变化及临床意义。方法临床收集106例高血压脑出血患者脑脊液标本为实验组,另外选取92例脑脊液标本为对照组。应用放射免疫技术测定患者24h、1周及2周脑脊液中β-内啡肽(β-EN,β-endorphin)的含量变化。结果测试发现高血压脑出血后β-内啡肽在脑脊液中的含量有明显变化,与脑损伤程度和疾病转归有密切关系。实验组所有脑脊液标本中β-内啡肽含量显著高于对照组(P<0.05)。结论高血压脑转出血患者脑脊液中β-内啡肽的含量有明显改变,对疾病的临床转归有预测价值。
Objective To investigate the changes and clinical significance of β-endorphin in cerebrospinal fluid in patients with hypertensive intracerebral hemorrhage. Methods The cerebrospinal fluid of 106 patients with hypertensive intracerebral hemorrhage was collected as the experimental group and 92 cases of cerebrospinal fluid were selected as the control group. The content of β-endorphin in cerebrospinal fluid (CSF) of patients at 24h, one week and two weeks was measured by radioimmunoassay. Results The levels of β-endorphin in cerebrospinal fluid after hypertensive intracerebral hemorrhage were significantly changed, which were closely related to the degree of brain injury and the outcome of the disease. The content of β-endorphin in all CSF samples in the experimental group was significantly higher than that in the control group (P <0.05). Conclusion The content of β-endorphin in cerebrospinal fluid of patients with hypertensive intracerebral hemorrhage has obviously changed, which has predictive value for the clinical outcome of the disease.