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目的探讨联合检测孕妇促甲状腺激素(TSH)及甲状腺过氧化物酶抗体(TPOAb)在产前筛查中的意义。方法将188例甲状腺功能正常的孕妇(孕16-24w)按照促甲状腺激素(TSH)参考范围为0.34-5.60IU/ml,分为甲状腺功能紊乱组61例和非甲状腺功能紊乱组127例,采用化学发光法(CIA)检测血清促甲状腺激素(TSH)和甲状腺过氧化物酶抗体(TPOAb)。结果甲状腺功能紊乱组TPOAb阳性率高达29.5%,非甲状腺功能紊乱组TPOAb阳性率也达到3.93%;181例孕妇中TPOAb阳性者23例,23例TPOAb阳性的孕妇中,有5例TSH异常(15%),165例TPOAb阴性的孕妇中,有3例TSH异常(1.8%)。结论 TPOAb阳性的孕妇甲状腺功能紊乱明显增加,TPOAb阳性的孕妇甲状腺功能有向亚临床甲状腺功能亢进或减退的趋势。
Objective To explore the significance of combined detection of thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) in prenatal screening. Methods 188 pregnant women with normal thyroid function (pregnancy 16-24w) were divided into thyroid dysfunction group (n = 61) and non-thyroid dysfunction group (n = 127) according to TSH reference range of 0.34-5.60IU / ml. Serum thyrotropin (TSH) and thyroid peroxidase antibody (TPOAb) were detected by chemiluminescence (CIA). Results The positive rate of TPOAb in thyroid dysfunction group was 29.5%, and the positive rate of TPOAb in non-thyroid dysfunction group was 3.93%. Among the 181 pregnant women, 23 were positive for TPOAb and 5 of the 23 TPOAb-positive pregnant women were abnormal in TSH %). Of the 165 TPOAb-negative pregnant women, 3 had TSH abnormalities (1.8%). Conclusion TPOAb-positive pregnant women significantly increased thyroid dysfunction, TPOAb-positive pregnant women with thyroid function have a tendency to subclinical hyperthyroidism or diminished.