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目的观察在常规标准药物治疗基础上联合应用前列腺素E1注射液对缺血性心肌病患者心脏功能的影响。方法选择缺血性心肌病心功能Ⅱ～Ⅳ级患者132例,随机分为两组。常规标准药物治疗组68例(对照组),在常规标准药物基础上联合应用前列腺素E1治疗64例(治疗组),两周后观察患者临床症状、心脏功能及血液流变学的变化。结果 (1)两组显效率和总有效率分别为52.94&(36/68)和92.65%(63/68)明显高于对照组的40.63%(26/64)和84.38%(54/64),差异有统计学意义(P<0.01)。治疗后,治疗组和对照组心脏功能各指标有明显的改善(P<0.05)。结论在常规标准药物治疗基础上联合应用前列腺素E1注射液治疗缺血性心肌病,能迅速改善心脏功能,改善血液流变性,消除临床症状,可广泛用于治疗缺血性心肌病心功能不全患者。
Objective To observe the effect of prostaglandin E1 injection on cardiac function in patients with ischemic cardiomyopathy on the basis of routine standard medical therapy. Methods 132 patients with ischemic cardiomyopathy grade Ⅱ ~ Ⅳ were randomly divided into two groups. Sixty-eight patients (control group) received routine prostaglandin E1 treatment on the basis of routine standard drugs. Two weeks later, their clinical symptoms, cardiac function and hemorheology were observed. Results (1) The apparent effective rate and total effective rate were 52.94% (36/68) and 92.65% (63/68) in the two groups respectively, which were significantly higher than those in the control group (40.63%, 26/64) and 84.38% (54/64) , The difference was statistically significant (P <0.01). After treatment, the indexes of cardiac function in the treatment group and the control group were significantly improved (P <0.05). Conclusion The combination of prostaglandin E1 injection on the basis of routine standard medical therapy for ischemic cardiomyopathy can rapidly improve cardiac function, improve blood rheology and eliminate clinical symptoms, and can be widely used in the treatment of ischemic cardiomyopathy heart failure patient.