1952年,Godwin提出“良性淋巴上皮病”(简称BLL),并指出构成病损的淋巴细胞或上皮细胞存在恶变的可能性。1953年Morgan提出,上皮肌上皮岛的概念。不少学者认为:当涎腺肿大为唯一症状,组织学上存在密集淋巴细胞浸润和上皮肌上皮岛时,称为BLL。一般认为,BLL、Sicca Syndrome(口干综合征)和Sigren Syndrome(简称SS)系同一病变的不同临床过程,BLL不一定发展为SS,SS的三个主要症状可能仅出现1～2个。BLL的发病率较低,约为3%。恶性淋巴上皮病变(简称MLEL)是发生于涎腺的罕见恶性肿瘤。Ferlito等认为本病是原发性。但目前多数学者认为,系由 In 1952, Godwin proposed “benign lymphoepithelial disease” (abbreviated as BLL) and pointed out the possibility of malignancy in lymphocytes or epithelial cells that constitute the lesion. In 1953 Morgan presented the concept of epithelial-muscular epithelial island. Many scholars believe that when the parotid gland enlargement is the only symptom, histologically there is dense lymphocyte infiltration and epithelial muscle epithelial island, it is called BLL. It is generally believed that BLL, Sicca Syndrome (somnia) and Sigren Syndrome (referred to as SS) are different clinical processes of the same lesion. BLL does not necessarily develop into SS, and the three main symptoms of SS may only occur in 1-2 cases. The incidence of BLL is low, about 3%. Malignant lymphoepithelial lesions (MLEL) are rare malignancies that occur in the parotid gland. Ferlito et al. consider this disease to be primary. But at present, most scholars believe that