论文部分内容阅读
目的：合成二氢吡啶介导的脑定向转释磺胺甲口恶唑药物。方法：以磺胺甲口恶唑和烟酸为原料，经酰化，烃化和还原反应制备［ 二氢吡啶磺胺甲口恶唑］ 偶联物。结果：［ 二氢吡啶磺胺甲口恶唑］ 偶联物及其中间体均经波谱鉴定。结论：本文结果为深入开发脑定向转释抗菌药物提供了重要参数
OBJECTIVE: To synthesize dihydropyridine-mediated translocation of sulfamethoxazole by brain orientation. Methods: Sulfamethoxazole and nicotinic acid were used as starting materials to prepare [dihydropyridine-sulfamethoxazole] conjugate via acylation, alkylation and reduction reactions. Results: [Dihydropyridine sulfamethoxazole] conjugates and their intermediates were identified by spectroscopy. Conclusion: The results of this paper provide important parameters for further development of antimicrobial agents for brain orientation-directed release