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目的研究胃癌组织中ｐ５３和Ｃｍｙｃ的表达与多药耐药性（ＭＤＲ）的关系．方法应用ＬＳＡＢ免疫组织化学方法研究６７例（男４１例，女２６例，平均年龄４６±１５８岁）胃癌标本中ｐ５３，Ｃｍｙｃ和Ｐｇｐ的表达．结果本组胃癌中ｐ５３阳性３２例（４７８％），Ｃｍｙｃ阳性３７例（５５２％），Ｐｇｐ阳性３９例（５８２％）．淋巴结转移阳性胃癌ｐ５３阳性率（５６９％）和Ｃｍｙｃ阳性率（６４７％）显著高于淋巴结转移阴性的胃癌（Ｐ＜００５）．ｐ５３的异常表达与ｍｄｒ１基因表达呈显著正相关（ｒ＝０６３，Ｐ＜００５），而Ｃｍｙｃ和ｍｄｒ１的表达无明显相关．结论ｐ５３异常表达可增加ｍｄｒ１基因的表达，从而使胃癌细胞获得ＭＤＲ表型
Objective To study the relationship between the expression of p53 and Cmyc and multidrug resistance (MDR) in gastric cancer. Methods The expressions of p53, Cmyc and Pgp in gastric cancer specimens of 67 patients (41 males and 26 females, mean age 46±158 years) were studied by LSAB immunohistochemistry. RESULTS: In this group, 32 cases (47.8%) of p53 were positive, 37 cases (55. 2%) were C-myc positive, and 39 cases (58. 2%) were P-gp positive. The positive rates of p53 (56.9%) and C-myc (64.7%) in gastric cancer with lymph node metastasis were significantly higher than those with negative lymph node metastasis (P<0. 05). The abnormal expression of p53 was positively correlated with the expression of mdr1 gene (r=063, P<005), but the expression of Cmyc and mdr1 was not significantly correlated. Conclusions The abnormal expression of p53 can increase the expression of mdr1 gene, so that gastric cancer cells can obtain the MDR phenotype.