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目的观察缬沙坦分散片联合雷公藤多甙对糖尿病肾病患者蛋白尿疗效。方法观察我院2009年1月至10月我科住院及门诊的60例2型糖尿病患者为研究对象,24h尿蛋白定量≥1.0g,血清肌酐(SCr)<265.2Umol/L,随机分为2组,对照组应用常规剂量的缬沙坦分散片80mg/次,2次/d,治疗组在应用常规剂量的缬沙坦分散片80mg/次,2次/d的基础上,给予雷公藤多甙40mg/d,,疗程2个月,观察治疗前后24h尿蛋白定量。结果治疗组与对照组24h尿蛋白定量均减少,但治疗组下降率高于对照组。结论在常规治疗基础上,加用雷公藤多甙可在一定程度上降低糖尿病肾病患者蛋白尿水平。
Objective To observe the effect of valsartan dispersible tablets combined with tripterygium glycosides on proteinuria in patients with diabetic nephropathy. Methods 60 patients with type 2 diabetes who were hospitalized and outpatient from January to October 2009 in our hospital were enrolled. The urinary protein excretion of 24h was ≥1.0g and the serum creatinine (SCr) <265.2Umol / L were randomly divided into 2 groups Group, the control group of conventional doses of valsartan dispersible tablets 80mg / times, 2 times / d, the treatment group in the conventional dose of valsartan dispersible tablets 80mg / times, 2 times / d basis, giving Tripterygium and more Glycosides 40mg / d ,, course of 2 months, 24h urine protein before and after treatment to observe the quantitative. Results The urinary protein excretion of the treatment group and the control group decreased 24 hours, but the reduction rate of the treatment group was higher than that of the control group. Conclusion On the basis of routine treatment, adding tripterygium glycosides can reduce the level of proteinuria in patients with diabetic nephropathy to a certain extent.