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目的探讨奥美拉唑联合山莨菪碱治疗急性胰腺炎的治疗效果。方法选取2010年1月~2013年12月在我院消化科治疗的急性胰腺炎病例160例,从中选出符合研究标准的样本病例50例进行回顾性分析。将50例病例按照单双数分成治疗组和对照组,每组病例各25例。两组病例采用不同的治疗方法,治疗组使用奥美拉唑联合山莨菪碱,并且附带常规治疗。奥美拉唑(常州四药制药有限公司)40mg,静脉输液2次/d,山莨菪碱20mg融入250ml生理盐水,静脉输液2次/d,治疗时间7d为一个疗程。对照组单独使用奥美拉唑(常州四药制药有限公司)40mg,静脉输液2次/d,7d为一个疗程。两组病例的常规治疗内容包括,禁食、禁水、胃肠减压、镇静、止痛、吸氧、保证电解质平衡、营养支持、适当的抗生素防止感染。结果治疗组在使用奥美拉唑联合山莨菪碱治疗后效果明显,治疗组总有效率为92%。对照组单独使用奥美拉唑进行治疗,总有效率为60%。从7d的治疗结果来看治疗组的效果明显要优于对照组。治疗组的各项病症消失较快,治疗组的治疗时长明显短于对照组。两组病例治疗前后,胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇CHDL-C)均存在明显改变。结论在急性胰腺炎的临床治疗中,奥美拉唑联合山莨菪碱的疗效优于单独使用奥美拉唑。
Objective To investigate the therapeutic effect of omeprazole combined with anisodamine in the treatment of acute pancreatitis. Methods A total of 160 cases of acute pancreatitis treated in Department of Gastroenterology from January 2010 to December 2013 in our hospital were selected. Fifty cases of the patients who met the criteria of the study were selected for retrospective analysis. The 50 cases were divided into treatment group and control group according to single and double number, each group of 25 cases. Two groups of patients treated with different methods, the treatment group used omeprazole combined anisodamine, and with conventional treatment. Omeprazole (Changzhou Siyao Pharmaceutical Co., Ltd.) 40mg, intravenous infusion 2 times / d, anisodamine 20mg into 250ml saline, intravenous infusion 2 times / d, the treatment time 7d for a course of treatment. The control group alone omeprazole (Changzhou Siyao Pharmaceutical Co., Ltd.) 40mg, intravenous infusion 2 times / d, 7d for a course of treatment. Routine treatment in both groups included fasting, water abatement, decompression of the gastrointestinal tract, sedation, analgesia, oxygenation, electrolyte balance, nutritional support, and appropriate antibiotics to prevent infection. Results After treatment with omeprazole and anisodamine in treatment group, the effect was obvious. The total effective rate was 92% in the treatment group. The control group treated with omeprazole alone, the total effective rate was 60%. From the 7d treatment results of the treatment group was significantly better than the control group. Treatment group of the symptoms disappear faster, the treatment group was significantly shorter duration of treatment than the control group. Before and after treatment, TC, TG, LDL-C and CHDL-C in both groups were significantly changed. Conclusion Omeprazole combined with anisodamine is superior to omeprazole alone in the clinical treatment of acute pancreatitis.