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在中药制剂中添加挥发油是制剂过程中经常碰到的工作。由于中药挥发油一般具有容易挥散和疏水性的特点,因此为了在制剂过程中尽量减少挥发油的损失,又使得挥发油与药物的其它成分能混和均匀,在制剂时需掌握一定的技巧。兹结合工作实践,谈谈我们在这方面的几点经验和体会,供有关同志参考。1.在冲剂中添加挥发油,一般均采用往干颗粒中喷晒挥发油的方法。我们在研制半夏露冲剂时,开始时也是采取这种工艺方法。将半夏露冲剂制成颗粒后,往颗粒中喷晒薄荷油。喷完后将冲剂置密闭容器中贮存一段时间后,分装,即得。这种方法避免了添加薄荷油后的加热过程,从表面上看薄荷油在工艺过程的损失较小,但是由于薄荷油只是吸咐于冲剂的表面,因此在包装和贮存过程中,薄荷油极易从冲剂表面脱附而挥散。如果采用铝塑包装或其它密封性能好的包装材料,则还能在冲剂中保留一部分薄荷油。如果选用聚乙烯薄膜作包装材料,那么半夏露冲剂贮存二周以上后,薄荷油就跑
The addition of volatile oils to traditional Chinese medicine preparations is a common task in the formulation process. Since volatile oils of traditional Chinese medicines are generally characterized by easy volatilization and hydrophobicity, in order to minimize the loss of volatile oils during the preparation process, volatile oils and other components of drugs can be mixed evenly, and certain skills must be mastered in the preparation. In connection with work practices, we will talk about some of our experiences and experiences in this regard for reference by relevant comrades. 1. In the granules to add volatile oil, are generally used to spray dried volatile oil particles. When we developed the Banxialu granules, we started with this process. After the Pinellia decoction is pelleted, peppermint oil is sprayed into the pellets. After spraying, the granules shall be stored in a closed container for a period of time and then packed. This method avoids the heating process after adding peppermint oil. From the surface, the loss of peppermint oil in the process is small, but because the peppermint oil is only sucked on the surface of the powder, the peppermint oil is used during the packaging and storage. Easy to desorb from the surface of the granules. If you use aluminum plastic packaging or other packaging materials with good sealing properties, you can still retain a part of peppermint oil in the granules. If polyethylene film is used as the packaging material, peppermint oil will be run after storage of the Pinellia Decoction for more than two weeks.