既往多认为,巨噬细胞是抗肿瘤免疫调节过程中的一种重要细胞群,可以直接杀伤肿瘤细胞,或者通过呈递肿瘤相关抗原诱导机体免疫应答从而清除肿瘤。但是近年来逐渐认识到,肿瘤间质中的巨噬细胞即肿瘤相关巨噬细胞(tumor-associated macrophages,TAM)并非发挥抗肿瘤作用,而是参与了 Previously think that macrophages is an important cell population in the anti-tumor immune regulation process, which can directly kill tumor cells or clear tumor by presenting tumor-associated antigens to induce immune response. However, in recent years, it has gradually come to realize that tumor-associated macrophages (TAMs), which are macrophages in the tumor stroma, are not involved in antitumor activities but are involved