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研究~(134)Cs诱发放射免疫毒理效应揭示,可致骨髓和胸腺细胞~3H-TdR掺入率明显下降,且胸腺细胞的受抑程度要比骨髓细胞更为显著。~(134)Cs 可致外周血和脾淋巴细胞中T淋巴细胞对PHA的转化反应和B-淋巴细胞对LPS的转化反应受抑,刺激指数降低。T淋巴细胞对~(134)Cs辐射损伤效应要比B淋巴细胞更加敏感。而外周免疫器官中淋巴细胞的辐射敏感性要比中枢免疫器官高。研究~(134)Cs诱发放射遗传毒理效应揭示,可致体细胞中骨髓细胞染色体畸变率明显增升,并诱发PCE微核率显著升高。对生殖细胞,可诱发精原细胞染色体畸变,使畸形精子率明显增加。且在骨髓细胞染色体畸变率、PCE微核率和畸形精子发生率与~(134)Cs的吸收剂量之间均呈现幂函数关系。
The study of ~ (134) Cs-induced radioimmunological toxicological effects revealed that ~ 3H-TdR incorporation was significantly decreased in bone marrow and thymocytes, and thymocytes were more inhibited than bone marrow cells. ~ (134) Cs can cause the transformation reaction of T lymphocytes to PHA in peripheral blood and splenic lymphocytes and the transformation reaction of B-lymphocytes to LPS are inhibited, and the stimulation index is decreased. T lymphocytes on ~ (134) Cs radiation damage than B lymphocytes more sensitive. Peripheral immune organs in lymphocyte radiation sensitivity than the central immune organs. Studies on ~ (134) Cs-induced genotoxicity revealed that the rate of chromosome aberrations in bone marrow cells was significantly increased in somatic cells and the rate of micronuclei in PCE cells was significantly increased. Germ cells, can induce chromosome aberrations of spermatogonia, so that the rate of abnormal sperm increased significantly. And there was a power function relationship between chromosome aberration rate, micronucleus rate of PCE and abnormal spermatogenesis rate and absorption dose of ~ (134) Cs in bone marrow cells.