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目的探讨胰腺癌的发生与血型及丙型肝炎病毒感染的相关性,为预防与治疗胰腺癌提供理论指导依据。方法回顾性分析2012年5月-2015年4月医院肝胆胰外科收治60例胰腺癌患者临床资料,应用多变量回归方法分析ABO血型和丙型肝炎病毒感染与胰腺癌的相关性。结果胰腺癌患者中A、B、O型及AB血型所占比例分别为30.00%、28.33%、30.00%及11.67%;患者为A型血与胰腺癌的发生存在相关性,差异有统计学意义(OR1.39,95%Cl1.01~1.81,P<0.05);患者HCV抗体呈阳性、有糖尿病史、吸烟史、酗酒史均是导致胰腺癌的高危因素。结论 A血型和丙型肝炎病毒感染均会增加患者胰腺癌发生的风险。
Objective To investigate the correlation between the occurrence of pancreatic cancer and blood group and hepatitis C virus infection and provide the theoretical basis for the prevention and treatment of pancreatic cancer. Methods The clinical data of 60 patients with pancreatic cancer admitted to our hospital from May 2012 to April 2015 were analyzed retrospectively. The association between ABO blood group and hepatitis C virus infection and pancreatic cancer was analyzed by multivariate regression analysis. Results The proportion of type A, B, O and AB blood was 30.00%, 28.33%, 30.00% and 11.67% respectively in patients with pancreatic cancer. There was a significant correlation between the type A blood and the incidence of pancreatic cancer (OR1.39,95% Cl1.01 ~ 1.81, P <0.05). HCV antibody was positive in patients with diabetes mellitus, smoking history and history of alcohol abuse were the risk factors of pancreatic cancer. Conclusion Both A and C infections increase the risk of pancreatic cancer in patients.