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目的探讨复方丹参注射液对子痫前期患者外周血CD152及vWF的影响作用,分析其治疗的机制。方法选取2015年1月—2016年6月期间在该院治疗的子痫前期住院患者134例进行比较分析。所有病例分为二组即对照组和观察组,其中对照组76例,观察组58例;二组均进行常规治疗,观察组加用复方丹参注射液予以治疗。采用流式细胞仪检测各组患者外周血中的CD152含量,应用ELISA法检测外周血中的vWF含量;并对所得结果进行统计分析。结果治疗后二组外周血中CD152含量明显降低,观察组外周血中CD152含量明显低于对照组(P<0.05);治疗后二组外周血中vWF含量明显降低,观察组外周血中vWF含量明显低于对照组(P<0.05)。结论复方丹参注射液可有效降低子痫前期患者外周血中CD152和vWF含量,改善患者免疫平衡状态,降低炎症反应,有效控制子痫前期病程发展。
Objective To investigate the effect of compound Danshen injection on CD152 and vWF in peripheral blood of preeclampsia patients and to analyze its mechanism of treatment. Methods A total of 134 inpatients with preeclampsia treated in our hospital from January 2015 to June 2016 were selected for comparative analysis. All cases were divided into two groups that the control group and the observation group, of which 76 cases in the control group, observation group 58 cases; two groups were routine treatment, the observation group plus compound Salvia injection to be treated. The content of CD152 in peripheral blood of each group was detected by flow cytometry. The content of vWF in peripheral blood was detected by ELISA, and the result was statistically analyzed. Results After treatment, the levels of CD152 in the peripheral blood of the two groups were significantly decreased. The content of CD152 in the peripheral blood of the observation group was significantly lower than that of the control group (P <0.05). After treatment, the vWF content in the peripheral blood of the two groups was significantly decreased. Significantly lower than the control group (P <0.05). Conclusions Fufang Danshen injection can effectively reduce the levels of CD152 and vWF in the peripheral blood of patients with preeclampsia, improve the immune balance, reduce the inflammatory reaction and effectively control the progression of preeclampsia.