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作者在泰国曼谷和差春骚府的日托中心挑选了634名2～6岁健康儿童进行了随机双盲安慰剂对照现场试验。菌苗每剂含3×10~9个伤寒杆菌Ty21a株、安慰剂每剂含2×10~9个加热灭活的大肠杆菌K-12株,均含有25mg甜味剂,冻干后用铝箔袋包装。服菌苗时先将一个包装的缓冲液材料(含1.3gNaHCO_3,0.8g抗坏血酸)溶于50ml水中,再加1份菌苗或安慰剂,轻轻摇匀后立即喝下。服菌苗前、后1小时内不进食,但可饮水,服菌苗后观察1小时。隔天口服1剂,共3剂。接种第1剂前和后21天采静脉血、收
The authors conducted a randomized, double-blind, placebo-controlled field trial of 634 healthy children aged 2-6 years at day care centers in Bangkok, Thailand and Charmansawu. The bacterins contained 3 × 10 ~ 9 typhoid strains Ty21a per dose and the placebo contained 2 × 10 ~ 9 heat-inactivated Escherichia coli K-12 strains each containing 25 mg of sweetener. After lyophilization, Bag packaging. Take a package of buffer material (containing 1.3gNaHCO_3, 0.8g ascorbic acid) in 50ml of water, add 1 part of vaccine or placebo and shake gently and drink immediately. Take bacterins before and after 1 hour without eating, but can drink water, take bacterin observed after 1 hour. Oral 1 day, a total of 3 doses. Venous blood was collected before and 21 days after the first dose of vaccination