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应用免疫组织化学方法（ＬＳＡＢ）法，检测５１例胃肠道平滑肌肉瘤（ＡＬＳ）中ｐ５３基因蛋白产物的表达情况，探讨ｐ５３蛋白的表达与ＡＬＳ组织学分级、预后相关因素的关系。结果显示，ＡＬＳ中ｐ５３蛋白阳性率为４４％；ｐ５３蛋白在组织学Ⅱ～Ⅲ级中的阳性率明显高于Ⅰ级（Ｐ＜０．０５），死亡组ｐ５３的阳性率高于生存组（Ｐ＜０．０５）。表明ｐ５３蛋白基因突变与胃肠道平滑肌肉瘤的发生、发展有关，ｐ５３蛋白可做为临床估计ＡＬＳ预后的客观参考指标。
The expression of p53 gene protein in gastrointestinal leiomyosarcoma (ALS) was detected by immunohistochemical method (LSAB). The relationship between the expression of p53 protein and histological grading and prognosis was investigated. The results showed that the positive rate of p53 protein in ALS was 44%; the positive rate of p53 protein in histological grades II-III was significantly higher than that of grade I (P<0.05). The positive rate of p53 in death group was higher than that of survival group ( P<0.05). The p53 protein gene mutation is associated with the occurrence and development of gastrointestinal leiomyosarcoma. p53 protein can be used as an objective reference index for the clinical prognosis of ALS.