微生物如何应答外界因素刺激在宿主体内繁殖、致病一直是微生物工作者关注的热点。最近有两组科学家应用微生物基因组最新进展对此进行了深入研究,获得了新的发现。Graham和Clark-Curtiss课题组采用一种称为选择性捕获转录序列(SCOTS)的方法对结核杆菌在人巨噬细胞内的反应作了研究,发现众多基因发生了转录,分别与 Microbial how to respond to external factors to stimulate reproduction in the host body, pathogenic microorganisms have been the focus of attention. Recently, two groups of scientists applied the latest progress of the microbial genome to further investigate this and obtained new findings. Graham and Clark-Curtiss’s group used a method called selective capture transcription (SCOTS) to study the response of Mycobacterium tuberculosis to human macrophages and found that many genes were transcribed