通道是药物作用的直接靶向部位,通道的研究与药物设计密切相关。近年来,随着基因重组技术和新型电生理方法应用于通道研究,以及天然动物毒素作为探针和合成钾通道调控剂的出现,已使钾通道的研究具有可靠的技术,加上钾通道是一类分布很广的膜离子通道,在平滑肌、心肌、腺体等组织中具有极其重要和复杂的作用。目前,钾通道已成为通道研究的热点。钾通道开放剂能增加细胞膜对钾离子的通透性,导致膜超极化, Channel is the direct target of drug action. The study of channel is closely related to drug design. In recent years, with the application of gene recombination techniques and novel electrophysiological methods to channel studies, and the appearance of natural animal toxins as probes and the synthesis of potassium channel modulators, the study of potassium channels has been made with reliable techniques, coupled with the fact that potassium channels are A wide range of distribution of membrane ion channels in the smooth muscle, myocardium, glands and other tissues has an extremely important and complex role. At present, potassium channel has become a hot research channel. Potassium channel openers can increase the cell membrane permeability of potassium ions, leading to membrane hyperpolarization,