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目的观察前列地尔联合甲钴胺治疗糖尿病周围神经病变(DPN)的疗效。方法将100例DPN患者随机分成2组,各50例,对照组采用甲钴胺肌内注射,治疗组在对照组用药基础上加用前列地尔静脉滴注,2周后对比2组疗效。结果治疗组改善DPN患者临床症状的总有效率为90%,对照组为64%,差异有统计学意义(P<0.01);周围神经传导速度均有明显改善,但治疗组优于对照组(P<0.05)。结论前列地尔联合甲钴胺治疗DPN可明显提高治疗效果。
Objective To observe the efficacy of prostaglandin combined with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods One hundred cases of DPN were randomly divided into two groups, 50 cases in each group. The control group received intramuscular injection of mecobalamin. The treatment group was given alprostadil intravenously on the basis of the control group, and the two groups were compared after 2 weeks. Results The total effective rate of clinical symptoms in DPN patients was 90% in the treatment group and 64% in the control group (P <0.01). The peripheral nerve conduction velocity was significantly improved, but the treatment group was better than the control group P <0.05). Conclusions Prostaglandin combined with mecobalamin in the treatment of DPN can significantly improve the therapeutic effect.