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目的 :探讨慢性乙肝患者应用促肝细胞生长素治疗前后CD系列阳性细胞的变化和淋巴细胞转化率的变化 ,以及两者的相关性。方法 :6 0例慢乙肝患者在促肝细胞生长素治疗前后检测CD系列阳性细胞和淋巴细胞转化率 ,与正常对照进行比较。结果 :促肝细胞生长素治疗后慢性乙肝患者CD+ 8细胞有明显减低 (P <0 .0 5 ) ,CD+ 3 /CD+ 8比值有明显提高 (P <0 .0 5 ) ,淋巴细胞转化率亦有显著提高 (P <0 .0 5 ) ,均基本恢复到正常人水平。CD+ 8细胞变化与淋巴细胞转化率呈明显负相关 (r=0 .83,P <0 .0 5 ) ,CD+ 4/CD+ 8比值与淋巴细胞转化率呈显著正相关 (r=0 .93,P <0 .0 1) 。结论 :促肝细胞生长素能调整慢性乙肝患者细胞免疫功能。
Objective: To investigate the changes of CD-positive cells and lymphocyte transformation rate in patients with chronic hepatitis B before and after treatment with hepatocyte growth-promoting factor, and the correlation between them. Methods: Sixty cases of chronic hepatitis B patients were tested for CD-positive cells and lymphocyte transformation rate before and after the treatment of hepatocyte growth-promoting factor, and compared with the normal control. Results: CD + 8 cells in patients with chronic hepatitis B were significantly decreased (P <0.05), and the ratio of CD + 3 / CD + 8 was significantly increased (P <0.05). The rate of lymphocyte transformation (P <0.05), all of which returned to the normal level. There was a significant negative correlation between CD + 8 cells and lymphocyte transformation rate (r = 0.83, P <0.05), CD + 4 / CD + 8 ratio and lymphocyte transformation rate (r = P <0 .0 1). Conclusion: HGF can regulate cellular immune function in chronic hepatitis B patients.