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目的对比吡柔比星(THP)膀胱灌注结合口服复方扶芳藤合剂与单纯THP膀胱灌注在非肌层浸润性膀胱癌(NMIBC)经尿道膀胱肿瘤切除(TURBT)术后的疗效,探讨复方扶芳藤合剂在膀胱癌术后治疗的作用。方法选取我院2012-2015年收治的NMIBC患者72例作为研究对象,全部患者均行TURBT术,术后病理结果明确为NMIBC。随机将术后患者分为A组和B组。A组36例,单独给予THP膀胱灌注化疗,每周1次,共8次,以后每月1次,至术后1年。B组36例,在膀胱灌注THP化疗的基础上,给予复方扶芳藤合剂口服,每天2次,每次15mL,疗程至术后半年。随访观察1年,对比两组的膀胱肿瘤复发情况、尿常规白细胞计数、不良反应情况和生活质量评分。结果 72例中有62例完成研究。术后半年及1年,两组肿瘤复发率比较差异无统计学意义,P>0.05)。两组尿常规白细胞计数、不良反应发生率及生活质量评分对比,术后1个月和2个月差异有统计学意义,P<0.05;术后3个月和6个月差异无统计学意义,P>0.05。结论复方扶芳藤额合剂能减轻THP膀胱灌注带来的膀胱刺激征及肉眼血尿等不良反应,同时改善症状,提高患者的生活质量。
Objective To compare the curative effect of intravesical instillation of pirarubicin (THP) combined with oral Fufang Funtang and pure THP bladder irrigation after transurethral bladder tumor resection (TURBT) in non-muscle invasive bladder cancer (NMIBC) Fang vine mixture in the treatment of bladder cancer after surgery. Methods Seventy-two patients with NMIBC admitted from 2012 to 2015 in our hospital were enrolled in this study. TURBT was performed in all patients. The postoperative pathological results were clearly NMIBC. Patients were randomly divided into A group and B group. A group of 36 patients were given THP bladder chemotherapy alone, once a week for a total of 8 times, once a month until after 1 year. Group B, 36 cases of bladder perfusion THP chemotherapy based on the given Fufang Fu Teng mixture oral 2 times a day, each 15mL, treatment to six months after surgery. Followed up for 1 year, compared the two groups of bladder tumor recurrence, urinary routine white blood cell count, adverse reactions and quality of life scores. Results Of the 72 patients, 62 completed the study. Six months and one year after operation, there was no significant difference in tumor recurrence between the two groups (P> 0.05). There were significant differences in urinary routine white blood cell count, incidence of adverse reactions and quality of life between the two groups at 1 month and 2 months postoperatively, P <0.05; there was no significant difference at 3 months and 6 months after operation , P> 0.05. Conclusion Fufang Fufang mixture can reduce bladder irritation caused by THP and gross hematuria and other adverse reactions, while improving symptoms and improve the quality of life of patients.