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目的对宿迁市新生儿先天性甲状腺功能减退症(CH)的筛查、诊断、治疗和随访进行总结和分析。方法样品采集用干滤纸血片法,采用时间分辨荧光免疫法检测血斑中促甲状腺素(TSH)。结果对110683名新生儿筛查结果显示,初筛阳性病例64例,确诊57例,总发病率0.51‰。结论先天性CH患儿于新生儿早期体内甲状腺激素已发生异常变化,故可经新生儿期进行筛查,使患儿得到早期诊断和及时治疗,减少残疾儿的发生,提高人口素质。
Objective To summarize and analyze the screening, diagnosis, treatment and follow-up of congenital hypothyroidism (CH) in newborns in Suqian. Methods Samples were collected using dry filter paper blood film method, the use of time-resolved fluorescence immunoassay for the detection of thyroid-stimulating hormone (TSH) in blood spots. Results The screening results of 110 683 newborns showed that 64 cases of primary screening were positive, 57 cases were diagnosed, the total incidence was 0.51 ‰. Conclusions Congenital CH children have abnormal changes of thyroid hormones in early neonates. Therefore, they can be screened in the neonatal period so that they can be diagnosed and treated promptly to reduce the incidence of disabled children and improve the population quality.