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目的:观察新生鼠缺氧缺血性脑损伤(HIBD)发生后闪光视觉诱发电位(F-VEP)的波形变化特征,探讨F-VEP对HIBD的早期监测作用。方法:80只SD新生鼠随机分为假手术组、HIBD组,每组各40只,按动物模型建立后 0、6、12、24、48h分为五个时段,每组各时段均为8只,采用闪光刺激法检测视觉诱发电位。结果:(1)7日龄SD新生鼠F-VEP有一分化良好的正向波。(2)HIBD组0、6、12、24、48h潜伏期延长,与对应各时段的假手术组比较均有非常显著性差异(P<0.001)。结论:(1)新生鼠HIBD发生时,F-VEP波形迅速发生改变,主要表现为潜伏期延长。(2)缺氧后持续异常的F-VEP提示HIBD存在,有助于HIBD的早期监测。
Objective: To observe the waveform changes of flash visual evoked potentials (F-VEP) after hypoxic-ischemic brain damage (HIBD) in newborn rats and to investigate the early monitoring effect of F-VEP on HIBD. Methods: Eighty SD newborn rats were randomly divided into sham operation group and HIBD group, 40 rats in each group. According to the animal models, they were divided into five periods at 0, 6, 12, 24 and 48 hours, each time period was 8 Only, using flash stimulation test visual evoked potentials. Results: (1) There was a well-differentiated positive wave in F-VEP of 7-day-old SD neonatal rats. (2) The latency of 0, 6, 12, 24, 48h in HIBD group was longer than that in sham operation group (P <0.001). Conclusions: (1) The F-VEP waveform changes rapidly in neonatal rats with HIBD, which is mainly manifested by prolonged latency. (2) The persistent abnormalities after hypoxia prompted the presence of HIBD in F-VEP, which is helpful for the early monitoring of HIBD.