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[目的]探讨血清中免疫球蛋白IgG、IgA、IgM及其轻链κ和λ含量、κ/λ比值以及补体C3、C4、B因子(PFB)含量在慢性肾功能不全(CRT)诊疗中的应用价值。[方法]在特定蛋白仪上,采用免疫速率散射比浊法测定IgG、IgA、IgM及其κ和λ含量以及C3、C4、PFB含量,并且计算κ/λ比值。[结果]与36例正常对照组比较,49例CRF患者血清中免疫球蛋白IgG、IgM,C3含量及κ/λ比值均降低,而免疫球蛋白IgA、轻链λ和C4含量则均升高。[结论]血清中免疫球蛋白IgG、IgA、IgM及其轻链κ和λ含量、κ/λ比值以及补体C3、C4、PFB含量检测对CRF的临床诊疗有重要的意义。
[Objective] To investigate the relationship between serum immunoglobulin IgG, IgA, IgM, light chain κ and λ, kappa / λ ratio and complement C3, C4, B factor (PFB) in the diagnosis and treatment of chronic renal insufficiency Value. [Methods] IgG, IgA, IgM, kappa and lambda, C3, C4 and PFB contents of IgG, IgA and IgM were measured by specific immunosensor. The ratio of kappa to lambda was calculated. [Results] The serum immunoglobulin IgG, IgM, C3 contents and kappa / lambda ratio in 49 CRF patients decreased compared with those in 36 normal controls, while the contents of immunoglobulin IgA, light chain lambda and C4 were all increased . [Conclusion] The serum immunoglobulin IgG, IgA, IgM, the light chain κ and λ content, κ / λ ratio and the levels of complement C3, C4 and PFB are of great significance in the clinical diagnosis and treatment of CRF.