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潘托拉唑(pantoprazole)是苯并咪唑新的衍生物,通过与壁细胞的H~+K~+-ATP酶共价结合而抑制胃酸分泌。作者研究了潘托拉唑治疗十二指肠溃疡的疗效和安全性,同时与雷尼替丁进行临床比较。 材料与方法:病人选自26个中心,年龄18～75岁,均经胃镜检查明确诊断有十二指肠溃疡(直径0.5～2.0 cm)。剔除溃疡并发出血、穿孔或内镜下有明确的返流性食管炎者。实验前5天禁用抗酸剂和抗溃疡药物,前三十天禁用苯并咪唑类药物和铋剂。所有病人分为两组,
Pantoprazole is a novel benzimidazole derivative that inhibits gastric acid secretion by covalently binding to the parietal H ~ + K ~ + -ATPase. The authors studied the efficacy and safety of the pantoprazole in the treatment of duodenal ulcer and compared it with ranitidine. MATERIALS AND METHODS: The patients were selected from 26 centers aged 18-75 years. Gastroduodenal ulcers (0.5-2.0 cm in diameter) were diagnosed by gastroscopy. Excluding ulcers and bleeding, perforation or endoscopic clear reflux esophagitis were. Antacids and anti-ulcer drugs were banned 5 days prior to the experiment, and benzimidazole and bismuth were banned for the first 30 days. All patients were divided into two groups,