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本研究利用ＢＡＥＰ检测对２７例应用常规剂量氨基甙类抗生素（链霉素、庆大霉素、卡那霉素）的患儿进行门诊随访研究，以了解此类药物的耳毒性及远期影响。２７例中，男１７例，女１０例。用药时平均年龄２岁零４个月（２个月～８岁）。用药前均无听力障碍。随访时平均年龄１２岁（５岁～１９岁），随访时间最长１５年。最短３年。结果发现：２７例患儿中，１例听力稍差，１７例２２只耳ＢＡＥＰ异常，即Ⅰ、Ⅱ波潜伏期延长；Ⅰ－Ⅴ波峰间潜伏期缩短；耳间差＞０．４ｍｓ。随访中有４例患儿，治疗前ＢＡＥＰ正常，治疗后４天复查，ＢＡＥＰ异常３例。说明氨基甙类抗生素耳毒性副作用相当多见，而且出现较早；ＢＡＥＰ异常是其耳毒性的早期表现之一，可作为停药的指征。
In this study, BAEP was used to conduct an outpatient follow-up study in 27 children with conventional doses of aminoglycoside antibiotics (streptomycin, gentamicin, kanamycin) to understand the ototoxicity and long-term effects of these drugs . 27 cases, 17 males and 10 females. Medication when the average age of 2 years and 4 months (2 months to 8 years old). No hearing impairment before treatment. The mean age at follow-up was 12 years (range, 5 years to 19 years) and the longest follow-up was 15 years. The shortest 3 years. The results showed that: 1 of 27 children had a weaker hearing ability and 17 cases of BAEP abnormalities, ie, the latency of wave Ⅰ and Ⅱ was prolonged; the latency of wave Ⅰ-Ⅴ was shortened; the difference of ear was> 0.4ms. Four children were followed up, with normal BAEP before treatment, 4 days after treatment and 3 cases with abnormal BAEP. Description aminoglycoside ototoxic side effects quite common, and appear earlier; BAEP abnormalities is one of its early manifestations of ototoxicity can be used as an indication of withdrawal.