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目的：临床观察和评估替托尼定治疗急性痉挛性肌痛的有效性和安全性。方法：急性痉挛性肌痛６０例，男性３９例，女性２１例，年龄３９±ｓ９ａ。随机均分为３组，分别服用替托尼定１ｍｇ，ｔｉｄ，替托尼定１ｍｇ加双氯芬酸２５ｍｇ，ｔｉｄ，双氯芬酸２５ｍｇ，ｔｉｄ，共１４ｄ，观察在接触时、运动时、休息时及夜间在服药前后疼痛程度的变化；并记录不良反应。结果：３组服药ｄ４的总有效率分别为８１％，８３％和６５％。前２组的不良反应为轻微的嗜睡（１０％）。结论：替托尼定较双氯芬酸更快、更有效地解除痉挛性肌痛（Ｐ＜０．０５），合适剂量为３ｍｇ／ｄ。
OBJECTIVE: To observe and evaluate the efficacy and safety of tiotropine in the treatment of acute spastic myalgia. Methods: 60 cases of acute spastic myalgia, 39 males and 21 females, age 39 ± s9a. Were randomly divided into three groups, respectively, taking tiotropine 1mg, tid, tiotropidine 1mg plus diclofenac 25mg, tid, diclofenac 25mg, tid, a total of 14d, observed during exercise, rest, and night pain before and after taking the drug The degree of change; and record adverse reactions. Results: The total effective rate of d4 in the three groups was 81%, 83% and 65% respectively. Adverse events in the first two groups were mild drowsiness (10%). CONCLUSION: TITRONITRIN is faster and more effective in relieving spasmodic myalgia than diclofenac (P <0.05) at a dose of 3 mg / d.