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目的 :观察抗癫痫药物治疗前后癫痫患者血清细胞因子水平变化 ,探讨白细胞介素 - 2 (IL - 2 )、白细胞介素 - 6 (IL - 6 )、肿瘤坏死因子 -α(TNF -α)在癫痫神经免疫调节中的作用。方法 :采用放射免疫分析测定 4 3例癫痫患者抗癫痫药物治疗前后 ,血清IL - 2、IL - 6、TNF -α的水平 ,并与年龄和性别相匹配的 32例正常对照组进行比较。结果 :癫痫患者治疗前血清IL - 2、IL - 6、TNF -α水平均显著高于正常对照组 (p <0 0 0 1 ) ,经治疗后有 1 8人疗效显著。其发作次数降低 75 %以上 ,其中有若干病人其血清细胞水平明显降低 ,但总体水平差异呈无显著性 (p >0 0 5 ) ,其余 2 5人疗效较差 ,其水平改变不大 ,但部分反有升高。患者血清IL - 2浓度与IL- 6、TNF -α水平变化呈显著正相关。结论 :癫痫患者血清细胞因子水平增高 ,提示免疫系统处于活化状态 ,但治疗后细胞因子水平改变难以预测 ,即使疗效显著者 ,亦有一些明显降低。
Objective: To observe the changes of serum cytokines levels in patients with epilepsy before and after antiepileptic drugs treatment. To investigate the changes of serum cytokines in patients with epilepsy before and after antiepileptic treatment. Role of epilepsy in neuroimmunity regulation. Methods: Serum levels of IL - 2, IL - 6 and TNF - α were measured before and after antiepileptic treatment in 43 epileptic patients by radioimmunoassay, and compared with 32 healthy controls matched for age and sex. Results: The serum levels of IL - 2, IL - 6 and TNF - α in patients with epilepsy before treatment were significantly higher than those in the normal control group (p <0.01). After treatment, 18 patients had significant effects. The number of seizures decreased by 75% or more. Some of the patients had significantly lower levels of serum cytokines but no significant difference in overall level (p> 0.05). The remaining 25 patients were less effective and their levels did not change much Some anti-rise. There was a significant positive correlation between serum IL - 2 level and IL - 6 and TNF - α levels. CONCLUSIONS: Elevated serum levels of cytokines in patients with epilepsy suggest that the immune system is in an activated state. However, changes in cytokine levels after treatment are unpredictable, and some are significantly reduced even with significant effects.