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目的:观察百口开关饮联合常规化疗对食管癌所致吞咽困难患者的近期疗效。方法:将食管癌所致吞咽困难患者72例随机分为2组各36例,对照组采取常规化疗干预,观察组在对照组的基础上加用百口开关饮治疗,比较2组临床疗效、不良反应、治疗前后中医症状积分及卡氏评分。结果:有效率观察组为55.6%,对照组为50.0%,2组比较,差异无统计学意义(P>0.05)。治疗后,2组吞咽困难分级均明显下降(P<0.05);2组组间比较,差异无统计学意义(P>0.05)。治疗后,2组中医症状积分均明显下降(P<0.05),卡氏评分均明显上升(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。观察组出现恶心呕吐观察组为9例,对照组为20例,2组比较,差异有统计学意义(P<0.05)。结论:百口开关饮联合常规化疗能明显改善食管癌所致吞咽困难症状,显著降低恶心呕吐发生率,提高患者生存质量。
Objective: To observe the short-term curative effect of the combination of “BaiKuan switch” and routine chemotherapy on patients with dysphagia caused by esophageal cancer. Methods: Seventy-two patients with dysphagia caused by esophageal cancer were randomly divided into two groups (n = 36). The control group was given routine chemotherapy intervention. The observation group was treated with Baikankuan switch drink. The clinical efficacy, Adverse reactions, TCM symptom score and Karnofsky score before and after treatment. Results: The effective observation group was 55.6%, while the control group was 50.0%. There was no significant difference between the two groups (P> 0.05). After treatment, the grade of dysphagia in both groups were significantly decreased (P <0.05). There was no significant difference between the two groups (P> 0.05). After treatment, the symptom scores of TCM symptoms decreased significantly in both groups (P <0.05), and the Karnofsky scores increased significantly (P <0.05). The improvement of the above indexes in the observation group was more significant than that in the control group (P <0.05). There were 9 cases in the observation group and 20 cases in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The combination of “BaiKuan Switch Drink” and conventional chemotherapy can significantly improve dysphagia symptoms caused by esophageal cancer, significantly reduce the incidence of nausea and vomiting and improve the quality of life of patients.