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目的:研究犬体内顺铂聚乳酸微球(CDDP-PLA)药物动力学。方法:20只杂种狗随机分为栓塞组和对照组。栓塞组X线透视下CDDP-PLA经导管注入肝动脉,静脉取血,1 mg·kg-1微球。对照组CDDP,1 mg·kg-1,其他同前。3P97软件处理药-时数据,原子吸收法测定血药浓度。结果:血浆CDDP动力学过程为三室;肝动脉灌注后8 h肝组织CDDP浓度分别为(22.08±12.15)μg·ml-1(微球组)和(3.25±0.09)μg·ml-1(对照组),差异显著(P<0.05)。结论:CDDP-PLA具有良好的肝动脉栓塞性能,使栓塞部位组织CDDP浓度维持较长时间和较高浓度,同时降低体循环浓度,降低CDDP全身毒性。
Objective: To study the pharmacokinetics of cisplatin polylactic acid microspheres (CDDP-PLA) in dogs. Methods: 20 hybrid dogs were randomly divided into embolization group and control group. In the embolization group, CDDP-PLA was transcatheter into the hepatic artery by X-ray fluoroscopy, and the blood was taken from the venous vein, 1 mg · kg-1 microspheres. Control group CDDP, 1 mg · kg-1, the other with the previous. 3P97 software processing drug - time data, blood concentration determination by atomic absorption method. Results: The CDDP kinetics of plasma was three-compartment. The CDDP concentrations of hepatic tissue at 8 h after hepatic artery perfusion were (22.08 ± 12.15) μg · ml-1 and 3.25 ± 0.09 μg · ml-1, respectively Group), significant difference (P <0.05). Conclusion: CDDP-PLA has good hepatic arterial embolism, which can maintain the CDDP concentration in the embolization site for a long time and at a higher concentration, reduce the systemic circulation concentration and decrease the systemic toxicity of CDDP.