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复发性急性早幼粒细胞白血病(APL)患者15例,使用亚砷酸,剂量为每日5mg,持续2小时静脉点滴.出凝血及肝肾功能检查每周1次;外周血计数检查每周2次;骨髓细胞形态学检查每2周1次.结果2例在治疗早期死亡;进行评估的13例中,11例在第1疗程获得完全缓解(CR率84.6%),2例患者未获缓解.5例出现肝功能指标的异常.
Fifteen patients with recurrent acute promyelocytic leukemia (APL) were treated with arsenious acid at a dose of 5 mg daily and intravenously for 2 hours. Coagulation and liver and kidney function tests were performed once a week; Peripheral blood count was checked weekly 2 times; bone marrow cell morphology was performed every 2 weeks. Results 2 cases died early in treatment; of the 13 cases evaluated, 11 cases achieved complete remission in the first course (CR rate 84.6%), and 2 patients did not receive Remission. 5 cases of abnormal liver function indicators.