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米非司酮作为流产药物已广泛应用于临床。但是,约1％的妇女对米非司酮的抗孕激素效应无反应导致流产失败。其原因可能与孕激素受体(PR)异常有关。综述PR与米非司酮不敏感之间的关系,以指导米非司酮在临床上的应用。
Mifepristone as abortion drugs have been widely used in clinical. However, about 1% of women fail to respond to the anti-progesterone effect of mifepristone and cause abortion. The reason may be related to progesterone receptor (PR) abnormalities. The relationship between PR and mifepristone insensitivity was reviewed to guide the clinical application of mifepristone.