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近100年来,曾多次提出严重烧伤时存在一种毒性因子的可能性。1975年Schoenenberger终于成功地由烧伤的鼠皮以及严重烧伤患者的皮肤和血清中提取出一种对实验动物有致死毒性作用的脂蛋白复合物。研究发现,这种毒素对肝细胞有较强的亲和力,它可以使鼠肝细胞的超微结构发生和烧伤时相似的变化。作者也在实验中证实,给予毒素后,离体鼠肝的物质代谢和超微结构变化,与皮肤烧伤后的变化均很相似。
In the past 100 years, there have been many times that the possibility of a toxic factor exists in severe burns. In 1975, Schoenenberger finally succeeded in extracting a lipoprotein complex that is lethal to experimental animals from the skin and serum of burned mice and severely burned patients. The study found that this toxin has a strong affinity for the liver cells, which can make the mouse liver cells and ultrastructures similar changes occur when burns. The authors also confirmed in experiments that the substance metabolism and ultrastructural changes of isolated rat liver were similar to those after skin burns given the toxin.