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目的:探讨妊娠滋养细胞肿瘤(GTT)的治疗方法及疗效。方法:对251例GTT患者应用CMV方案(卡铂、氨甲蝶呤、长春新碱)及“双枪方案”(5-氟尿嘧啶、更生霉素)两种化疗方案的治疗效果及联合手术治疗的疗效结果进行回顾性分析。结果:251例GTT患者,完全缓解率88.05%。其中,CMV方案完全缓解率87.78%(79/90),“双枪方案”完全缓解率83.82%(57/68),两组间完全缓解率无显著性差异(P>0.05),两组间耐药性的产生有显著性差异(P<0.05),化疗副反应中,口腔溃疡、腹泻发生率有显著性差异(P<0.05)。单纯化疗完全缓解率86.08%(136/158),化疗联合手术治疗完全缓解率91.40%(85/93)。结论:CMV化疗方案,效果肯定,不易产生耐药性,且化疗副反应轻,临床较易执行,可作为一种治疗选择。对于具有手术指征的患者化疗后联合手术治疗,疗效更好。
Objective: To investigate the treatment and efficacy of gestational trophoblastic tumor (GTT). Methods: The curative effect of two chemotherapy regimens of CMV (carboplatin, methotrexate, vincristine) and “double gunshot regimen” (5-fluorouracil, dactinomycin) The curative effect of treatment was retrospectively analyzed. Results: In 251 patients with GTT, the complete remission rate was 88.05%. Among them, the complete remission rate was 87.78% (79/90) for CMV regimen and 83.82% (57/68) for double guns regimen, with no significant difference between the two groups (P> 0.05) There was significant difference (P <0.05) in drug resistance among groups. There was significant difference in the incidence of oral ulcer and diarrhea between chemotherapy side effects (P <0.05). The complete remission rate of simple chemotherapy was 86.08% (136/158), and the complete remission rate of chemotherapy combined with surgery was 91.40% (85/93). Conclusion: The chemotherapy regimen of CMV has definite effect, is not easy to produce drug resistance, and the side effects of chemotherapy are light and the clinical is easy to perform. It can be used as a treatment option. For patients with surgical indications combined with chemotherapy after chemotherapy, the effect is better.