目的探讨儿童及青少年脊柱肿瘤的临床特点、治疗方法及预后。方法对1987年1月～2002年6月间收治的43例儿童及青少年脊柱肿瘤患者进行回顾性分析,男31例,女12例;年龄3～16岁,平均11.8岁。瘤样病变11例(占25.6%),良性肿瘤13例(占30.2%),恶性肿瘤19例(占44.2%)。根据发病部位可分为颈椎15例,胸椎16例,腰椎6例,骶椎6例。除1例胸椎恶性淋巴瘤患者采取化疗外,其他患者均行手术治疗,根据病情的不同予以植骨融合或植骨融合内固定,所有恶性肿瘤患者术后均接受放疗或化疗。结果随访时间为1～10年,平均4.3年。良性肿瘤及瘤样病变患者术后疗效较满意,所有患者的局部疼痛和神经症状均有所好转,未出现病变复发、恶变;恶性肿瘤患者中有6例(原始神经外胚层瘤2例、Ewing瘤1例、神经母细胞瘤1例、浆细胞瘤1例、软骨肉瘤1例)因肿瘤转移、全身衰竭死亡,占总数的14.0%、恶性肿瘤的31.6%。1例骨巨细胞瘤、1例恶性神经鞘瘤分别于术后2.5年及10个月局部复发。1例FrankelA级和1例B级患者术后无明显改变,其余均有不同程度改善;3例由C级恢复至D级;8例由D级恢复至E级。结论儿童及青少年脊柱肿瘤中,良性肿瘤如果切除彻底,预后良好;恶性肿瘤治疗效果相对欠佳,有较高的复发及死亡率,其预后与肿瘤的性质、手术治疗的方式及术后的后续治疗 Objective To investigate the clinical features, treatment and prognosis of children and adolescent spinal tumors. Methods Retrospective analysis was performed on 43 cases of children and adolescent spinal tumors admitted from January 1987 to June 2002, including 31 males and 12 females, aged from 3 to 16 years with an average of 11.8 years. Tumor-like lesions in 11 cases (25.6%), benign tumors in 13 cases (30.2%), malignant tumors in 19 cases (44.2%). According to the site of disease can be divided into 15 cases of cervical spine, thoracic 16 cases, lumbar 6 cases, 6 cases of sacral. In addition to chemotherapy in 1 patient with thoracic malignant lymphoma, the other patients underwent surgical treatment. All patients underwent bone graft fusion or bone graft fusion and internal fixation. All patients with malignant tumors underwent radiotherapy or chemotherapy. Results The follow-up time was 1 to 10 years, an average of 4.3 years. The benign tumor and tumor-like lesions in patients with satisfactory efficacy after surgery, all patients with local pain and neurological symptoms have improved, no lesions recurrence, malignant transformation; malignant tumor patients in 6 cases (primitive neuroectodermal tumor in 2 cases, Ewing 1 tumor, 1 neuroblastoma, 1 plasmacytoma, 1 chondrosarcoma) died of systemic metastasis due to tumor metastasis, accounting for 14.0% of the total and 31.6% of malignant tumors. One case of giant cell tumor of bone and one case of malignant schwannoma recurred locally at 2.5 years and 10 months respectively. One case of Frankel A grade and one case of grade B patients had no significant change after operation, the rest were improved to varying degrees; three cases recovered from grade C to grade D; eight cases recovered from grade D to grade E. Conclusions In children and adolescent spinal tumors, benign tumors are well resected and the prognosis is good. Malignant tumors are relatively ineffective and have a high relapse and mortality rate. The prognosis and the nature of the tumor, the surgical treatment and follow-up treatment