建立大鼠胰腺腺泡细胞癌癌前病变的动物模型，了解该癌前病变及Ｋｒａｓ 基因突变的情况　雄性Ｗｉｓｔａｒ 大鼠单次腹腔注射重氮乙酰丝氨酸３０ｍｇ／Ｋｇ 体重，４ 个月后常规取胰腺组织行光镜和电镜检查，并应用ＰＣＲＳＳＣＰ法检测Ｋｒａｓ 基因突变情况　大鼠胰腺腺泡细胞癌癌前病变发生率１００％ ，Ｋｒａｓ 基因突变率４２－１ ％ 。重氮乙酰丝氨酸可成功诱导大鼠胰腺腺泡细胞癌癌前病变，Ｋｒａｓ 基因突变在此过程中属早期事件。 An animal model of precancerous lesions of rat pancreatic acinar cell carcinoma was established to understand the precancerous lesions and K ras mutations Male Wistar rats were given a single intraperitoneal injection of diazoacetylserine 30 mg/Kg body weight, 4 months later. The pancreatic tissue was examined by light microscopy and electron microscopy. The incidence of precancerous lesions of pancreatic acinar cell carcinoma in rats with Kras mutation was detected by PCRSSCP. The mutation rate of Kras gene was 42–1%. Diazoacetylserine can successfully induce precancerous lesions of pancreatic acinar cells in rats. K-ras mutations are early events in this process.