机体对吸入粉尘的最初反应是肺巨噬细胞的聚集和吞噬。细胞毒性粉尘使巨噬细胞崩解、死亡。已有证明肺灌洗可以精确地从肺泡部位取样。我们的研究已证实肺灌洗是一种操作比较简单、安全、相对无损伤性的新技术。因而研究肺灌洗液中肺巨噬细胞(PAM)坏变情况,对于评价生产环境、尘肺的诊断、疗效判断、预后估价,不仅具有理论价值,而且具有实用意义。为此 The body’s initial response to inhaled dust is the accumulation and phagocytosis of lung macrophages. Cytotoxic dust disrupts macrophages and dies. It has been demonstrated that lung lavage can accurately sample from the alveoli. Our research has confirmed that lung lavage is a relatively simple, safe, relatively non-invasive new technology. Therefore, it is not only of theoretical value but also of practical significance to study the damage of lung macrophages (PAM) in lung lavage fluid for the evaluation of the production environment, the diagnosis of pneumoconiosis, the judgment of curative effect and the prognosis. to this end